- Obesity and Metabolism
- Metformin-Associated Lactic Acidosis: Predisposing Factors and Outcome
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Min Ju Kim, Ju Young Han, Jun Young Shin, Shin Il Kim, Jeong Min Lee, Seongbin Hong, So Hun Kim, Moon Suk Nam, Yong Seong Kim
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Endocrinol Metab. 2015;30(1):78-83. Published online March 27, 2015
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DOI: https://doi.org/10.3803/EnM.2015.30.1.78
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- Background
Metformin is considered the first choice oral treatment for type 2 diabetes patients in the absence of contraindications. Rarely, life-threatening complications associated with metformin treatment are seen in some patients with underlying diseases. The aim of this study was to further investigate the clinical profiles and risk factors for metformin-associated lactic acidosis (MALA) and the treatment modalities according to survival. MethodsTo identify MALA, we performed a retrospective study in seven diabetic patients who were taking metformin and had been diagnosed with lactic acidosis at Inha University Hospital between 1995 and 2012. For each patient, we recorded the age, sex, daily metformin dosage, laboratory test results, admission diagnosis, and risk factors. Also, concurrent conditions, treatment modalities, and outcomes were evaluated. ResultsSix patients had risk factors for lactic acidosis before admission. All patients had renal impairment on admission as a precipitating risk factor. Five patients survived and two patients died despite early renal replacement therapy. Older patients tended to have a poorer prognosis. ConclusionRenal function must be monitored in elderly type 2 diabetes mellitus patients with underlying diseases and conditions causing renal impairment who begin metformin treatment. Accurate recognition of MALA and initiation of renal replacement are essential for treatment.
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Citations
Citations to this article as recorded by  - An Analysis of Clinical Outcomes of Exploratory Pediatric Metformin Ingestions Reported to the Texas Poison Center Network From 2011 to 2021
Shawn M. Varney, Sarah Watkins, Haylea Stuteville, Mark L. Winter, Han Tony Gao, Thomas G. Martin, Ryan P. Morrissey, Wayne R. Snodgrass, Brett A. Roth
Hospital Pharmacy.2024;[Epub] CrossRef - Metformin Treatment Reduces the Incidence of Rheumatoid Arthritis: A Two-Sample Mendelian Randomized Study
Jialin Liang, Yuanqing Cai, Jianan Zhang, Zhaopu Jing, Leifeng Lv, Guangyang Zhang, Rupeng Zhang, Ruiyu Liu, Kai Nan, Xiaoqian Dang
Journal of Clinical Medicine.2023; 12(7): 2461. CrossRef - PLGA-based microspheres loaded with metformin hydrochloride: Modified double emulsion method preparation, optimization, characterization, and in vitro evaluation
Priyanka Chauhan, Himanshu Paliwal, Chetan Singh Chauhan, Ankit Paliwal
Annales Pharmaceutiques Françaises.2023; 81(6): 997. CrossRef - Metformin-associated lactic acidosis: underlying multiple myeloma
Clara GOMES, Ana FERREIRA, Neuza SOARES, Vanessa CHAVES, Luís LEMOS, Sofia TAVARES, Marta COUTO
Gazzetta Medica Italiana Archivio per le Scienze Mediche.2022;[Epub] CrossRef - Metformin-associated lactic acidosis and factors associated with 30-day mortality
Kanin Thammavaranucupt, Boonchan Phonyangnok, Watanyu Parapiboon, Laddaporn Wongluechai, Watthikorn Pichitporn, Jirut Sumrittivanicha, Somnuek Sungkanuparph, Arkom Nongnuch, Kulapong Jayanama, Donovan Anthony McGrowder
PLOS ONE.2022; 17(8): e0273678. CrossRef - Metformin Associated Lactic Acidosis in Clinical Practice – A Case Series
Philipp Schädle, Otto Tschritter, Monika Kellerer
Experimental and Clinical Endocrinology & Diabetes.2021; 129(11): 842. CrossRef - Effect of continuous use of metformin on kidney function in diabetes patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
Qi Yu, Jia-Jia Zhu, Wen-Xian Liu
BMC Cardiovascular Disorders.2020;[Epub] CrossRef - Metformin: current clinical applications in nondiabetic patients with cancer
Kailin Chen, Yajun Li, Zhen Guo, Yong Zeng, Wei Zhang, Hui Wang
Aging.2020; 12(4): 3993. CrossRef - Specifics of diabetes in old age
Markéta Kubíčková
Interní medicína pro praxi.2019; 21(4): 223. CrossRef - The Association between Metformin Therapy and Lactic Acidosis
Isabelle H. S. Kuan, Ruth L. Savage, Stephen B. Duffull, Robert J. Walker, Daniel F. B. Wright
Drug Safety.2019; 42(12): 1449. CrossRef - Metformin overdose: A serious iatrogenic complication—Western France Poison Control Centre Data Analysis
Alexandre Stevens, Jean‐François Hamel, Ali Toure, Samy Hadjadj, David Boels
Basic & Clinical Pharmacology & Toxicology.2019; 125(5): 466. CrossRef - Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery
Laura N. Deden, Edo O. Aarts, Stephanie C. W. Aelfers, Marcel M. G. J. van Borren, Ignace M. C. Janssen, Frits J. Berends, Hans de Boer
Obesity Surgery.2018; 28(4): 1080. CrossRef - Metformin-related lactic acidosis: Case report
Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba C
Colombian Journal of Anesthesiology.2017; 45(4): 353. CrossRef - Metformin-related lactic acidosis: Case report☆
Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba C
Colombian Journal of Anesthesiology.2017; 45(4): 353. CrossRef - Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes
Eun Young Lee, Sena Hwang, Yong-ho Lee, Seo Hee Lee, Young Mi Lee, Hua Pyong Kang, Eugene Han, Woonhyoung Lee, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee
Yonsei Medical Journal.2017; 58(2): 312. CrossRef - Hypoglycemia and severe lactic acidosis in a dog following metformin exposure
Nicole Barrella, Beth Eisenberg, Stephanie Nicole Simpson
Clinical Case Reports.2017; 5(12): 2097. CrossRef - Acidosis láctica por metformina: reporte de caso
Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba C
Revista Colombiana de Anestesiología.2017; 45(4): 353. CrossRef - Towards natural mimetics of metformin and rapamycin
Alexander Aliper, Leslie Jellen, Franco Cortese, Artem Artemov, Darla Karpinsky-Semper, Alexey Moskalev, Andrew G. Swick, Alex Zhavoronkov
Aging.2017; 9(11): 2245. CrossRef - Metformin-Associated Lactic Acidosis
Martin R. Hevesy
Advanced Emergency Nursing Journal.2017; 39(1): 26. CrossRef - Metformin associated lactic acidosis (MALA): clinical profiling and management
Alessandra Moioli, Barbara Maresca, Andrea Manzione, Antonello Maria Napoletano, Daniela Coclite, Nicola Pirozzi, Giorgio Punzo, Paolo Menè
Journal of Nephrology.2016; 29(6): 783. CrossRef - Risk assessment and management of post-transplant diabetes mellitus
Eugene Han, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
Metabolism.2016; 65(10): 1559. CrossRef - Temporal trends in the use of antidiabetic medicines: a nationwide 9-year study in older people living in New Zealand
Prasad S. Nishtala, Mohammed Saji Salahudeen
Therapeutic Advances in Drug Safety.2016; 7(5): 184. CrossRef - Metformin-associated lactic acidosis: Current perspectives on causes and risk
Ralph DeFronzo, G. Alexander Fleming, Kim Chen, Thomas A. Bicsak
Metabolism.2016; 65(2): 20. CrossRef - Lactic acidosis and the relationship with metformin usage
Weiyi Huang, Ronald L. Castelino, Gregory M. Peterson
Medicine.2016; 95(46): e4998. CrossRef - Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states
Hye Suk Kang, Ho-Chan Cho, Jae-Ho Lee, Goo Taeg Oh, Seung-Hoi Koo, Byung-Hyun Park, In-Kyu Lee, Hueng-Sik Choi, Dae-Kyu Song, Seung-Soon Im
Scientific Reports.2016;[Epub] CrossRef - Metformin-associated lactic acidosis: time to let it go?
Chantal Mathieu
Journal of Diabetes and its Complications.2015; 29(8): 974. CrossRef - Metformin: risk-benefit profile with a focus on cancer
Nicoletta Provinciali, Matteo Lazzeroni, Massimiliano Cazzaniga, Franco Gorlero, Barbara K Dunn, Andrea DeCensi
Expert Opinion on Drug Safety.2015; 14(10): 1573. CrossRef
- Changes of Glucose Tolerance in Acromegaly Patients with 24 Hour Continuous Subcutaneous Infusion of Octreotide.
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Ki Hyun Baik, Kun Ho Yoon, Jeong Min Lee, Chang Wook Kim, Paek Sun Kim, Sang Aha Jang, Soon Jib Yoo, Hyun Sik Son, Moo II Kang, Bong Yun Cha, Kwang Woo Lee, Ho Young Son, Sung Koo Kang
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J Korean Endocr Soc. 1999;14(4):636-644. Published online January 1, 2001
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Abstract
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- BACKGROUND
An important metabolic feature of acromegaly is a reduced action of insulin on hepatic gluconeogenesis and peripheral glucose disposal which mediated by growth hormone hypersecretion. Octreotide, a synthetic octapeptide somatostatin analogue exerts complex effects on hormonal and metabolic regulations affecting glucose homeostasis. This study was designed to ascertain the shorterm effect of octreotide on glucose tolerance in acromegaly. METHODS: 10 patients (five men and five women, age 47.9+/-11.8) were injected subcutaneously with octreotide, 100 micrograms for 24 hours. Patients were assessed with respect to growth hormone, glucose, and insulin response to a standard 100 g oral glucose tolerance test (OGTT) before and during the last 2 hour of octreotide infusion. RESULTS: During the therapy, there was significant decrease in mean blood glucose response to OGTT (678.4+/-51.9 vs 581.9+/-47.3 mg/dL/2hr: mean areas under the glucose curve, p=0.01) and mean serum insulin response to oral glucose load was significantly reduced in all patients (339.2+/-106.2 vs 256.7+/-111.3 U/mL/2hr: mean areas under the insulin curve, p=0.01). Using glucose tolerance test criteria three patients of 10 had normal glucose tolerance, four and three had impaired glucose tolerance and diabetes, respectively, at base line. While on octreotide these composition was changed to six patients of NGT, three of IGT and one diabetes. CONCLUSION: We conclude that insulin resistance mediated by GH hypersecretion was improved by shorterm octreotide treatment.
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